Normally I don't tell people I'm into n=1 experimentation. Or biohacking. Because it sounds pretentious & weird.

Something a socially awkward person says at a party.


In truth, I'm so into n=1 experimentation and biohacking I have a blog about it. An you've found it!

Biohacking autoimmune & Biohacking Peak Experience is the byline.

But, as mentioned,  normally I don't say biohacking out loud.

Except recently. I was an evaluation conference at an airport hotel in Winnipeg and somehow, in that setting, it felt appropriate to speak about it.

Nobody knew what biohacking was, but all my fellow evaluators understood when I explained that I apply evaluative thinking to my personal life with the goal of maximizing my well-being. I run nutritional & lifestyle experiments, and use the data to fine-tune the strategies I use to achieve my goal.

In the company of other evaluation geeks, this made perfect sense.

That's because an evaluative midset is all that biohacking requires.

Biohacking as Research

Evaluation spiral

Evaluation is research, and can be divided according to 3 purposes:

  1. Summative Evaluation:  To make a judgement at the end of an intervention;
  2. Formative Evaluation: For improvement during an intervention;
  3. Developmental Evaluation: In complex, dynamic contexts when the intervention is adaptive rather than predetermined.

You can use all types for biohacking.

Summative Evaluation

Use summative evaluation when you follow an established elimination diet, like the Autoimmune Protocol (AIP). Gather data about your health & well-being before you start (that's your baseline), engage with the protocol exactly as prescribed, & gather data at the end. Then determine if it is worth continuing with the experiment. It's important to stay with the protocol long enough to generate useful summative data for evaluation.

Formative Evaluation

Formative evaluation improves an intervention. For example, if you've been on the AIP (or another protocol) for a reasonable length of time, and you aren't getting the interim results you hoped for, you might assess your fidelity to the protocol (are you following it exactly?) & discover that some refinements can be made in this area. Or you might level up to a coconut-free, low-FODMAP or a ketogenic version for a period of time, and continue to evaluate the results of this change.

Developmental Evaluation

Developmental Evaluation assists with learning & tracking progress when there is no predetermined intervention; conditions are complex; and causality is hard to track.

It assists with developing an intervention inside the mess of real life.

You might use it when nothing seems to be working and environments both inside and outside your body are unpredictable. Gradually, through self-experimentation, you might develop a pattern (an intervention) that can be evaluated formatively or summatively, but in the meantime, developmental evaluation allows you to observe and interact with complex systems and adapt as you go.

The internet has allowed people who are innovating in this way to communicate the results of their experiments with each other, enabling Developmental Biohackers to accelerate learning & pattern-finding.

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Take the Assessment

Biohacking is a way to use evaluation to achieve your wellness goals & change your life.

In my case that means achieving peak experience or flow more frequently. In Matthew's case it means reversing his disabling autoimmune conditions.

Mark Moschel calls biohacking a "systems-thinking approach to our own biology."


Evaluation is research.

Evaluation research includes "any effort to judge or enhance human effectiveness through systematic data-based inquiry" ~Michael Quinn Patton.

N=1, in the language of evaluation & research, simply means an experiment with 1 participant. You!

The assumption inherent to n=1 biohacking experiments is that universal solutions to complex problems can have limited effectiveness, as we each have unique histories, genetic profiles, environments and patterns of responding.

We are complex systems living in complex systems.

And an evaluative mindset is what we need to leverage this complexity on behalf of our health & well-being.

Featured Resource

Biohack U 1:1 Coaching

Experts in personalized (n=1) experimentation methods, Biohack U Coaches can help you get started with your own n=1 and can assist you with troubleshooting your healing process.

Joanna is a Certified Health Coach living in Australia. She focuses on helping people effect positive behavioral change through the personalization of their healing protocol lifestyle. 

Petra brings 25-years of experience in research and evaluation to her coaching practice. Her area of expertise is personalized experimentation (n=1) for healing & optimization.

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